CLASSIFICATION OF ESTRADURIN(R) BATCHES - CORRELATION BETWEEN P-31 NMR AND A BIOLOGICAL DURATION TEST FOR BATCH APPROVAL

被引：10

作者：

THELIN, B

LUNDSTEDT, T

LUNDGREN, R

OLSSON, A

BATRA, S

机构：

[1] PHARMACIA THERAPEUT,CTR STRUCT PROPERTY OPTIMIZAT,S-20180 MALMO,SWEDEN

[2] PHARMACIA ONCOL,S-25109 HELSINGBORG,SWEDEN

[3] PHARMACIA ONCOL,S-22363 LUND,SWEDEN

来源：

CHEMOMETRICS AND INTELLIGENT LABORATORY SYSTEMS | 1995年 / 27卷 / 01期

关键词：

D O I：

10.1016/0169-7439(94)00055-N

中图分类号：

TP [自动化技术、计算机技术];

学科分类号：

0812 ;

摘要：

The analyses used for batch approval of Estradurin(R) are a biological duration test on mice together with gel permeation chromatography. For 38 historical batches these analyses have been complemented with P-31 NMR analysis. In this work we have used multivariate methods such as principal components analysis, discriminant projections to latent structures and pattern recognition to find a correlation between the old and the new analyses for batch approval. In this way it has been possible to establish a mathematical model for approving/not approving batches of Estradurin(R) based on 31 P NMR analysis. This should make it possible to replace the animal duration test.

引用

页码：135 / 145

页数：11

共 7 条

[1] OPTIMIZATION IN ORGANIC-SYNTHESIS - STRATEGIES WHEN THE DESIRED REACTION IS ACCOMPANIED BY PARASITIC SIDE REACTIONS - AN EXAMPLE WITH ENAMINE SYNTHESIS [J].