CARBENOID TRANSFER TO IMINES - A NEW ASYMMETRIC CATALYTIC SYNTHESIS OF AZIRIDINES

被引：234

作者：

HANSEN, KB ^{[1
]}

FINNEY, NS ^{[1
]}

JACOBSEN, EN ^{[1
]}

机构：

[1] HARVARD UNIV, DEPT CHEM, CAMBRIDGE, MA 02138 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 1995年 / 34卷 / 06期

关键词：

ASYMMETRIC SYNTHESIS; AZIRIDINES; CHIRAL LIGANDS; COPPER COMPLEXES;

D O I：

10.1002/anie.199506761

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An azomethine ylide is invoked as an intermediate in the copper‐catalyzed addition of diazoesters to imines [Eq. (a)]. Coordinated to the chiral copper(I)–bis(dihydrooxazole) catalyst, these intermediates cyclize to produce enantiomerically enriched 1,3‐diaryl‐2‐carboxyethylaziridines (44–67% ee). (Figure Presented.) Copyright © 1995 by VCH Verlagsgesellschaft mbH, Germany

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页码：676 / 678

页数：3

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