MUCUS SYNTHESIS AND SULFHYDRYL-GROUPS IN CYTOPROTECTION MEDIATED BY DEHYDROLEUCODINE, A SESQUITERPENE LACTONE

被引:50
作者
GUARDIA, T
GUZMAN, JA
PESTCHANKER, MJ
GUERREIRO, E
GIORDANO, OS
机构
[1] UNIV SAN LUIS,DEPT FARMACOL,SAN LUIS,ARGENTINA
[2] UNIV NACL SAN LUIS,DEPT QUIM ORGAN,SAN LUIS,ARGENTINA
来源
JOURNAL OF NATURAL PRODUCTS | 1994年 / 57卷 / 04期
关键词
D O I
10.1021/np50106a010
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
The aerial parts of Artemisia douglasiana have been used in folk medicine as a cytoprotective agent against the development of peptic ulcer. Dehydroleucodine [1], its active principle, significantly prevents the formation of gastric lesions induced by the exposure of the rats to absolute EtOH. It was found in this study that (a) pretreatment of rats with 1 (40 mg/kg, po) caused a significant increase in glycoprotein synthetic activity, approximately sevenfold as large as that of the control; and (b) pretreatment of the rats with the thiol reagent N-methylmaleimide (NEM) significantly diminished the cytoprotection provided by 1. However, the protective effect of 1 was not totally abolished by pretreatment with a combination of indomethacin and NEM, indicating additional mechanisms are involved in the cytoprotective action of 1.
引用
收藏
页码:507 / 509
页数:3
相关论文
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