SYNTHESIS OF NEW STABLE FLUOROPROSTACYCLIN ANALOGS WITH POTENT ANTIANGINAL ACTIVITY

被引：17

作者：

ASAI, T ^{[1
]}

MORIZAWA, Y ^{[1
]}

SHIMADA, T ^{[1
]}

NAKAYAMA, T ^{[1
]}

URUSHIHARA, M ^{[1
]}

MATSUMURA, Y ^{[1
]}

YASUDA, A ^{[1
]}

机构：

[1] ASAHI GLASS CO LTD, RES CTR, KANAGAWA KU, YOKOHAMA, KANAGAWA 221, JAPAN

来源：

TETRAHEDRON LETTERS | 1995年 / 36卷 / 02期

关键词：

D O I：

10.1016/0040-4039(94)02217-Y

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Synthesis of new stable fluoroprostacyclins, 7-fluoro-2,4-methylene-17,20-dimethylprostacyclins (1, 2) with potent and long-lasting anti-anginal activities has been achieved via three-component coupling reaction and stereospecific fluorination.

引用

页码：273 / 276

页数：4

共 21 条

[1]

[Anonymous], 1993, ORGANOFLUORINE COMPO

[2] PROSTAGLANDIN CHEMISTRY .20. SYNTHESIS OF CHEMICALLY STABLE PROSTACYCLIN ANALOGS [J].

BANNAI, K ;

TORU, T ;

OBA, T ;

TANAKA, T ;

OKAMURA, N ;

WATANABE, K ;

HAZATO, A ;

KUROZUMI, S .

TETRAHEDRON, 1983, 39 (22) :3807-3819

[3]

BEZUGLOV VV, 1984, DOKL AKAD NAUK SSSR+, V277, P1400

[4] SYNTHESIS OF THERAPEUTICALLY USEFUL PROSTAGLANDIN AND PROSTACYCLIN ANALOGS [J].

COLLINS, PW ;

DJURIC, SW .

CHEMICAL REVIEWS, 1993, 93 (04) :1533-1564

[5]

Filler R., 1982, BIOMEDICAL ASPECTS F

[6] 10,10-DIFLUORO-13-DEHYDROPROSTACYCLIN - CHEMICALLY AND METABOLICALLY STABILIZED POTENT PROSTACYCLIN [J].

FRIED, J ;

MITRA, DK ;

NAGARAJAN, M ;

MEHROTRA, MM .

JOURNAL OF MEDICINAL CHEMISTRY, 1980, 23 (03) :234-237

[7]

Hudlicky M., 1988, ORG REACTIONS, V35, P513, DOI DOI 10.1002/0471264180.0R035.03

[8]

MARKOVSK.LN, 1973, SYNTHESIS-STUTTGART, P787

[9] PROSTAGLANDIN SYNTHESES BY 3-COMPONENT COUPLING [J].

NOYORI, R ;

SUZUKI, M .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 1984, 23 (11) :847-876

[10]

Noyori R., 1994, ASYMMETRIC CATALYSIS

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