ENANTIOSELECTIVE SYNTHESIS OF 2-ISOXAZOLINES VIA ASYMMETRIC 1,3-DIPOLAR CYCLOADDITION OF NITRILE OXIDE TO ACHIRAL ALLYL ALCOHOL

被引：70

作者：

UKAJI, Y

SADA, K

INOMATA, K

机构：

来源：

CHEMISTRY LETTERS | 1993年 / 11期

关键词：

D O I：

10.1246/cl.1993.1847

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The asymmetric 1,3-dipolar cycloaddition of a nitrile oxide to an achiral allyl alcohol was achieved by the use of (R,R)-diisopropyl tartrate as a chiral auxiliary. Treatment of the allyl alcohol with diethylzinc and the tartrate, followed by the addition of diethylzinc and a hydroximoyl chloride, afforded the corresponding (R)-2-isoxazolines with excellent enantioselectivity.

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页码：1847 / 1850

页数：4

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