Mental flexibility impairment in drivers with early Alzheimer's disease: A simulator-based study

After memory impairment, one of the most common troubles of early Alzheimer's disease (AD) is the impairment of executive functioning. However, it can have major consequences on daily life, notably on the driving activity. The present study focused on one important executive function involved in driving: mental flexibility; and considered how this impairment can affect driving. Ten patients with early AD were matched with 29 healthy older drivers. All participants were given an evaluation of mental flexibility through neuropsychological tests and an experimental test developed on a static driving simulator. The experiment was divided in two conditions; one without mental flexibility and another condition with a mental flexibility demand. AD patients showed impairments in the neuropsychological tests evaluating mental flexibility. These deficits are linked to the deficits they showed in the driving simulator flexibility tests. This study contributes to the understanding of mental flexibilitymechanismsand on their role in driving activity. It also confirms that the driving simulator is a suitable tool to explore cognitive disorders and driving ability. (C) 2013 International Association of Traffic and Safety Sciences. Production and hosting by Elsevier Ltd. All rights reserved.