T-CELL AUTOIMMUNITY IN TYPE-1 DIABETES-MELLITUS

被引：23
作者：
BIRK, OS
COHEN, IR
机构：
[1] The Weizmann Institute of Science, Rehovot
来源：
CURRENT OPINION IN IMMUNOLOGY | 1993年 / 5卷 / 06期
关键词：
D O I：
10.1016/0952-7915(93)90104-Z
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Insulin dependent diabetes mellitus is a T-cell mediated autoimmune disease. Several beta-cell antigens, mostly non-tissue-specific, have been implicated in the disease process. The antigens and the autoimmune T cells exist in healthy individuals, as do many of the genes required for the development of diabetes. The question, then, is why and how exposure to undefined environmental agents activates an existing autoimmune potential and directs it to damage the beta cells.
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页码：903 / 909
页数：7
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