A COMPARISON OF THE PREGNANCY-TERMINATING POTENCIES OF 3 ANTIPROGESTINS IN GUINEA-PIGS, AND THE EFFECTS OF SULPROSTONE

被引：4

作者：

POYSER, NL ^{[1
]}

FORCELLEDO, ML ^{[1
]}

机构：

[1] INST CHILENO MED REPROD,SANTIAGO,CHILE

来源：

PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS | 1994年 / 50卷 / 05期

关键词：

D O I：

10.1016/0952-3278(94)90161-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The anti-progestins mifepristone, lilopristone (ZK 98734) and HRP 2000 were equipotent at terminating the pregnancy of guinea-pigs during mid-gestation, although mifepristone was more effective at low doses. Sulprostone administration on the day following anti-progestin treatment tended to increase the effectiveness of mifepristone and HRP 2000, without affecting the time interval between the start of the antiprogestin treatment and the day of abortion. It is concluded that, of the three afferent anti-progestins used, none is more potent than the other two at terminating pregnancy in the animal model used. The co-administration of a prostaglandin E(2) (PGE(2)) analogue tends to increase the effectiveness of the anti-progestin.

引用

页码：245 / 247

页数：3

共 6 条

[1] PROGESTERONE-RECEPTOR BLOCKAGE - EFFECT ON UTERINE CONTRACTILITY AND EARLY-PREGNANCY [J].