INVITRO AND INVIVO CONSEQUENCES OF VLA-2 EXPRESSION ON RHABDOMYOSARCOMA CELLS

被引：315

作者：

CHAN, BMC

MATSUURA, N

TAKADA, Y

ZETTER, BR

HEMLER, ME

机构：

[1] HARVARD UNIV,SCH MED,DANA FARBER CANC INST,BOSTON,MA 02115

[2] HARVARD UNIV,CHILDRENS HOSP,DEPT SURG,BOSTON,MA 02115

[3] HARVARD UNIV,SCH MED,DEPT CELLULAR & MOLEC PHYSIOL,BOSTON,MA 02115

来源：

SCIENCE | 1991年 / 251卷 / 5001期

关键词：

D O I：

10.1126/science.2011740

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Cloned integrin alpha-2 subunit complementary DNA was expressed on human rhabdomyosarcoma (RD) cells to give a functional VLA-2 (alpha-2-beta-1) adhesion receptor. The VLA-2-positive RDA2 cells not only showed increased adhesion to collagen and laminin in vitro, but also formed substantially more metastatic tumor colonies in nude mice after either intravenous or subcutaneous injection. These results show that a specific adhesion receptor (VLA-2) can markedly enhance both experimental and spontaneous metastasis. In contrast to the metastasis results, there was no difference in either the in vitro growth rate or apparent in vivo tumorigenicity of RD and RDA2 cells.

引用

页码：1600 / 1602

页数：3

共 49 条

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