NUCLEAR AND CYTOPLASMIC BCL-2 EXPRESSION IN ENDOMETRIAL HYPERPLASIA AND ADENOCARCINOMA

被引:60
作者
CHAN, WK
MOLE, MM
LEVISON, DA
BALL, RY
LU, QL
PATEL, K
HANBY, AM
机构
[1] IMPERIAL CANC RES FUND,HISTOPATHOL UNIT,LONDON WC2A 3PN,ENGLAND
[2] GUYS HOSP,DEPT HISTOPATHOL,LONDON SE1 9RT,ENGLAND
[3] NORFOLK & NORWICH HOSP,DEPT HISTOPATHOL,NORWICH NR1 3SR,NORFOLK,ENGLAND
关键词
BCL-2; APOPTOSIS; ENDOMETRIAL CARCINOMA; ENDOMETRIAL HYPERPLASIA;
D O I
10.1002/path.1711770305
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The bcl-2 proto-oncogene, which inhibits programmed cell death (apoptosis), has recently been found to be cyclically expressed in human endometrium. In order to investigate its role in endometrial hyperlasia and neoplasia, bcl-2 expression was studied in 25 cases of endometrial carcinoma and 20 cases of endometrial hyperplasia (eight simple, two complex. and ten atypical hyperplasias). Uniform intense cytoplasmic bcl-2 expression was found in all cases of non-atypical hyperplasia, and less strong positivity in eight out of ten cases of atypical hyperplasia. In well-differentiated carcinomas, nine out of ten showed weak to moderate bcl-2 expression, whereas six out of seven poorly differentiated carcinomas were bcl-2-negative. Moderately differentiated tumours were an intermediate group, with six out of eight being positive. Widespread localization of bcl-2 protein to the chromosomes of dividing cells was also demonstrated, regardless of cytoplasmic bcl-2 expression, with rare staining of interphase nuclei. Our findings suggest a role for bcl-2 in the natural history of endometrial neoplasia and studies are needed to determine its usefulness as a prognostic marker. The finding of bcl-2 localization to chromosomes has important implications for its mode and site of action.
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页码:241 / &
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