AFRICAN BURKITTS-LYMPHOMA - A PLANT, EUPHORBIA-TIRUCALLI, REDUCES EPSTEIN-BARR VIRUS-SPECIFIC CELLULAR-IMMUNITY

被引：0
作者：
IMAI, S
SUGIURA, M
MIZUNO, F
OHIGASHI, H
KOSHIMIZU, K
CHIBA, S
OSATO, T
机构：
[1] HOKKAIDO UNIV, SCH MED, INST CANC, DEPT VIROL, SAPPORO 060, JAPAN
[2] KYOTO UNIV, FAC AGR, DEPT FOOD SCI & TECHNOL, KYOTO 606, JAPAN
[3] SAPPORO MED UNIV, DEPT PEDIAT, SAPPORO 060, JAPAN
来源：
ANTICANCER RESEARCH | 1994年 / 14卷 / 3A期
关键词：
BURKITTS LYMPHOMA; EPSTEIN-BARR VIRUS; AFRICAN PLANT SUBSTANCE; CELLULAR IMMUNITY;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Endemicity of Burkitt's lymphoma (BL) coincides with profusion of a plant Euphorbia tirucalli in tropical Africa. E. tirucalli contains 4-deoxyphorbol ester that enhances Epstein-Barr virus (EBV) infection of B lymphocytes. In this study, we found that 4-deoxyphorbol ester reduced EBV-specific cytotoxic T-cell function. Furthermore, the B lymphocytes dually exposed to EBV and 4-deoxyphorbol ester were resistant to EBV-specific T cell cytotoxicity, through down-regulation of latent membrane protein 1 (LMP1), the major target to EBV-specific cytotoxic T-cells. These immunologic findings strengthen the notion that E. tirucalli may be an important environmental risk factor for the genesis of African BL.
引用
收藏
页码：933 / 936
页数：4
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