ELEVATED BLOOD-PRESSURE AND CRANIOFACIAL ABNORMALITIES IN MICE DEFICIENT IN ENDOTHELIN-1

被引：852

作者：

KURIHARA, Y

KURIHARA, H

SUZUKI, H

KODAMA, T

MAEMURA, K

NAGAI, R

ODA, H

KUWAKI, T

CAO, WH

KAMADA, N

JISHAGE, K

OUCHI, Y

AZUMA, S

TOYODA, Y

ISHIKAWA, T

KUMADA, M

YAZAKI, Y

机构：

[1] UNIV TOKYO, FAC MED, DEPT INTERNAL MED 3, BUNKYO KU, TOKYO 113, JAPAN

[2] UNIV TOKYO, FAC MED, DEPT PATHOL, BUNKYO KU, TOKYO 113, JAPAN

[3] UNIV TOKYO, FAC MED, DEPT PHYSIOL, BUNKYO KU, TOKYO 113, JAPAN

[4] UNIV TOKYO, FAC MED, DEPT GERIATR, BUNKYO KU, TOKYO 113, JAPAN

[5] CHUGAI PHARMACEUT CO LTD, GOTEMBA, SHIZUOKA 412, JAPAN

[6] UNIV TOKYO, INST MED SCI, DEPT REPROD & DEV BIOL, MINATO KU, TOKYO 108, JAPAN

来源：

NATURE | 1994年 / 368卷 / 6473期

关键词：

D O I：

10.1038/368703a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The endothelin-l (ET-1) gene was disrupted in mouse embryonic stem cells by homologous recombination to generate mice deficient in ET-1. These: ET-1(-/-) homozygous mice die of respiratory failure at birth and have morphological abnormalities of the pharyngeal-arch-derived craniofacial tissues and organs. ET-1(+/-) heterozygous mice, which produce lower levels of ET-1 than wild-type mice, develop elevated blood pressure. These results suggest that ET-1 is essential for normal mouse development and may also play a physiological role in cardiovascular homeostasis.

引用

页码：703 / 710

页数：8

共 47 条

[1] THE HUMAN HOX GENE FAMILY [J].