THE KINETICS OF ENZYME-SYSTEMS INVOLVING ACTIVATION OF ZYMOGENS

被引:6
作者
HAVSTEEN, BH
GARCIAMORENO, M
VALERO, E
MANJABACAS, MC
VARON, R
机构
[1] UNIV CASTILLA LA MANCHA,ESCUELA POLITECN,DEPT QUIM FIS,CARRETERA PENAS,KM 3200,E-02006 ALBACETE,SPAIN
[2] UNIV KIEL,INST BIOCHEM,W-2300 KIEL 1,GERMANY
关键词
D O I
10.1007/BF02460651
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
A general model of zymogen activation is proposed and explicit kinetic equations for the time courses of the various species and products involved are given. These equations are valid for the whole course of the reaction and therefore for both the transient phase and the steady state. This model is sufficiently general to include mechanisms possessing one or more steps of zymogen activation besides possible steps of inhibition (reversible or irreversible) or inactivation.
引用
收藏
页码:561 / 583
页数:23
相关论文
共 29 条
[1]  
Chock P. B., 1980, METHOD ENZYMOL, V64, P297
[2]  
CHOCK PB, 1977, P NATL ACAD SCI USA, V74, P2766, DOI 10.1073/pnas.74.7.2766
[3]   KINETIC STUDIES OF UROKINASE-CATALYZED CONVERSION OF NH2-TERMINAL GLUTAMIC-ACID PLASMINOGEN TO PLASMIN [J].
CHRISTENSEN, U .
BIOCHIMICA ET BIOPHYSICA ACTA, 1977, 481 (02) :638-647
[4]   TRANSIENT PHASE KINETICS OF ENZYME-REACTIONS WHERE MORE THAN ONE SPECIES OF ENZYME IS PRESENT AT START OF REACTION [J].
DARVEY, IG .
JOURNAL OF THEORETICAL BIOLOGY, 1977, 65 (03) :465-478
[5]  
DAVIE EW, 1975, ANNU REV BIOCHEM, V44, P798
[6]  
DELSOLO CG, UNPUB AN QUIM
[7]   KINETIC-STUDY OF THE ACTIVATION PROCESS OF FROG EPIDERMIS PRO-TYROSINASE BY TRYPSIN [J].
GALINDO, JD ;
PENAFIEL, R ;
VARON, R ;
PEDRENO, E ;
GARCIACARMONA, F ;
GARCIACANOVAS, F .
INTERNATIONAL JOURNAL OF BIOCHEMISTRY, 1983, 15 (05) :633-637
[8]  
GALVEZ J, 1981, J THEOR BIOL, V19, P1
[9]  
GERALD CF, 1989, APPLIED NUMERICAL AN, P367
[10]   PANCREATIC PROTEINASES - THEIR ACTIVATION AND DISTURBANCES OF THIS MECHANISM IN MAN [J].
HADORN, B .
MEDICAL CLINICS OF NORTH AMERICA, 1974, 58 (06) :1319-1331