ASSOCIATION OF THE CARBOXY-TERMINUS OF BETA-AMYLOID PROTEIN-PRECURSOR WITH ALZHEIMER PAIRED HELICAL FILAMENTS

被引：30

作者：

CAPUTO, CB ^{[1
]}

SOBEL, IRE ^{[1
]}

SCOTT, CW ^{[1
]}

BRUNNER, WF ^{[1
]}

BARTH, PT ^{[1
]}

BLOWERS, DP ^{[1
]}

机构：

[1] ICI PLC,DIV PHARMACEUT,DEPT BIOTECHNOL,MACCLESFIELD SK10 4TG,CHESHIRE,ENGLAND

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1992年 / 185卷 / 03期

关键词：

D O I：

10.1016/0006-291X(92)91730-E

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We investigated whether a peptide fragment from the C-terminus of β-amyloid protein precursor is associated with Alzheimer paired helical filaments (PHFs). Antiserum BR188, to the last 20 amino acids of the precursor, did not cross-reac with tau protein, known to be in PHFs. It did react with all five pronase-treated PHF preparations assayed by ELISA and immunogold-labelled the same PHF fibrils that a PHF-specific tau antibody labelled. Neither antibody labelled β A4 fibrils. These results suggest that a fragment from the C-terminus of β-amyloid precursor protein copurifies with pronase-treated PHFs and may play a role in their molecular pathogenesis. © 1992.

引用

页码：1034 / 1040

页数：7

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