ACCESSORY PROTEIN FUNCTION IN THE DNA POLYMERASE-III HOLOENZYME FROM ESCHERICHIA-COLI

被引：21

作者：

ODONNELL, M

机构：

[1] Howard Hughes Medical Institute, Microbiology Department, Cornell University Medical College, New York, New York, 10021

来源：

BIOESSAYS | 1992年 / 14卷 / 02期

关键词：

D O I：

10.1002/bies.950140206

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

DNA polymerases which duplicate cellular chromosomes are multiprotein complexes. The individual functions of the many proteins required to duplicate a chromosome are not fully understood. The multiprotein complex which duplicates the Escherichia coli chromosome, DNA polymerase III holoenzyme (holoenzyme), contains a DNA polymerase subunit and nine accessory proteins. This report summarizes our current understanding of the individual functions of the accessory proteins within the holoenzyme, lending insight into why a chromosomal replicase needs such a complex structure.

引用

页码：105 / 111

页数：7

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