ACCESSORY PROTEIN FUNCTION IN THE DNA POLYMERASE-III HOLOENZYME FROM ESCHERICHIA-COLI

被引：21

作者：

ODONNELL, M

机构：

[1] Howard Hughes Medical Institute, Microbiology Department, Cornell University Medical College, New York, New York, 10021

来源：

BIOESSAYS | 1992年 / 14卷 / 02期

关键词：

D O I：

10.1002/bies.950140206

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

DNA polymerases which duplicate cellular chromosomes are multiprotein complexes. The individual functions of the many proteins required to duplicate a chromosome are not fully understood. The multiprotein complex which duplicates the Escherichia coli chromosome, DNA polymerase III holoenzyme (holoenzyme), contains a DNA polymerase subunit and nine accessory proteins. This report summarizes our current understanding of the individual functions of the accessory proteins within the holoenzyme, lending insight into why a chromosomal replicase needs such a complex structure.

引用

页码：105 / 111

页数：7

共 50 条

[21] INVITRO REPLICATION OF UV-IRRADIATED DNA WITH DNA POLYMERASE-III HOLOENZYME OF ESCHERICHIA-COLI [J].

LIVNEH, Z .

BRITISH JOURNAL OF CANCER, 1986, 54 (02) :360-360

[22] CONTRIBUTION OF 3'-]5' EXONUCLEASE ACTIVITY OF DNA POLYMERASE-III HOLOENZYME FROM ESCHERICHIA-COLI TO SPECIFICITY [J].

FERSHT, AR ;

KNILLJONES, JW .

JOURNAL OF MOLECULAR BIOLOGY, 1983, 165 (04) :669-682

[23] RECA PROTEIN INHIBITS INVITRO REPLICATION OF SINGLE-STRANDED-DNA WITH DNA POLYMERASE-III HOLOENZYME OF ESCHERICHIA-COLI [J].

SHWARTZ, H ;

LIVNEH, Z .

MUTATION RESEARCH, 1989, 213 (02) :165-173

[24] OVERPRODUCTION OF THE BETA SUBUNIT OF DNA POLYMERASE-III HOLOENZYME REDUCES UV MUTAGENESIS IN ESCHERICHIA-COLI [J].

TADMOR, Y ;

ASCARELLIGOELI, R ;

SKALITER, R ;

LIVNEH, Z .

JOURNAL OF BACTERIOLOGY, 1992, 174 (08) :2517-2524

[25] THE DNAN GENE CODES FOR THE BETA-SUBUNIT OF DNA POLYMERASE-III HOLOENZYME OF ESCHERICHIA-COLI [J].

BURGERS, PMJ ;

KORNBERG, A ;

SAKAKIBARA, Y .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1981, 78 (09) :5391-5395

[26] INTERACTION OF THE BETA-SUBUNIT OF ESCHERICHIA-COLI DNA POLYMERASE-III HOLOENZYME WITH THE CATALYTIC CORE [J].

LADUCA, R ;

CRUTE, J ;

MCHENRY, C ;

BAMBARA, R .

JOURNAL OF CELLULAR BIOCHEMISTRY, 1986, :235-235

[27] THE GAMMA-SUBUNIT OF DNA POLYMERASE-III HOLOENZYME OF ESCHERICHIA-COLI IS PRODUCED BY RIBOSOMAL FRAMESHIFTING [J].

FLOWER, AM ;

MCHENRY, CS .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (10) :3713-3717

[28] DNA POLYMERASE-III HOLOENZYME - SUBUNITS AND FUNCTION [J].

MAKI, H ;

MAKI, S ;

LASKEN, R ;

KORNBERG, A .

JOURNAL OF CELLULAR BIOCHEMISTRY, 1986, :125-125

[29] DNA POLYMERASE-III HOLOENZYME OF ESCHERICHIA-COLI .4. THE HOLOENZYME IS AN ASYMMETRIC DIMER WITH TWIN ACTIVE-SITES [J].

MAKI, H ;

MAKI, S ;

KORNBERG, A .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1988, 263 (14) :6570-6578

[30] MUTATOR STRAINS OF ESCHERICHIA-COLI, MUTD AND DNAQ, WITH DEFECTIVE EXONUCLEOLYTIC EDITING BY DNA POLYMERASE-III HOLOENZYME [J].

ECHOLS, H ;

LU, C ;

BURGERS, PMJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1983, 80 (08) :2189-2192

← 1 2 3 4 5 →