NUCLEAR-MAGNETIC-RESONANCE AS A TOOL FOR THE IDENTIFICATION OF SPECIFIC DNA-LIGAND INTERACTION

被引：17
|
作者：
ROSSI, C
DONATI, A
SANSONI, MR
机构：
[1] Department of Chemistry, University of Siena, 53100 Siena
来源：
CHEMICAL PHYSICS LETTERS | 1992年 / 189卷 / 03期
关键词：
D O I：
10.1016/0009-2614(92)85139-2
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
In this paper, a method based on NMR measurements for studying the ability of ligands to interact with DNA is proposed. Via R1(SE) and R1(NS) spin-lattice relaxation rate analysis and temperature dependence, it is possible to investigate the DNA-ligand complexing. This approach appears very appropriate for testing the affinity of pollutants and others chemicals in the environment towards nucleic acid. As a standard method for large-scale screening of molecules resulting from human activity, it could be very useful for identifying potential mutagens and toxic compounds.
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页码：278 / 280
页数：3
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