SKIN COLLAGEN CHANGES RELATED TO AGE AND HORMONE REPLACEMENT THERAPY

被引：146
作者：
CASTELOBRANCO, C
DURAN, M
GONZALEZMERLO, J
机构：
[1] Department of Gynaecology and Obstetrics, Hospital Clinic i Provincial de Barcelona, School of Medicine
来源：
MATURITAS | 1992年 / 15卷 / 02期
关键词：
ESTROGENS; SKIN; COLLAGEN; AGE; MENOPAUSE;
D O I：
10.1016/0378-5122(92)90245-Y
中图分类号：
R592 [老年病学]; C [社会科学总论];
学科分类号：
03 ; 0303 ; 100203 ;
摘要：
A total of 76 nulliparous women who had been hospitalized for minor operations, classified according to age group (by decade from 20s to 60s) and 118 postmenopausal women randomly allocated to one of four groups were studied. In all, 312 skin biopsies were taken from the lower abdomen at 0 and 12 months and the skin collagen changes noted. Collagen content decreased significantly with age beyond the 40s (P < 0.001) and after the menopause (P < 0.01). The decrease was preventable by the use of hormone replacement therapy. All the therapeutic regimens induced increases in skin collagen content, whereas in the control group a significant decrease was observed (P < 0.05).
引用
收藏
页码：113 / 119
页数：7
相关论文
共 19 条
[11]  
LINDSAY R, 1989, SCHWEIZ MED WSCHR, V119, P1806
[12]  
Lopez De Leon A, 1985, J HISTOCHEM CYTOCHEM, V33, P737
[13]  
NEUMAN RE, 1950, J BIOL CHEM, V186, P549
[14]  
PUNNONEN R, 1971, ACTA OBSTET GYN SCAN, V50, P32
[15]  
PUNNONEN R, 1971, BASIC ACTIONS SEX ST, P254
[16]  
PUNNONEN R, 1973, ACTA OBSTET GYNAEC S, V21, P1
[17]   THE EFFECT OF PERCUTANEOUS ESTRADIOL AND NATURAL PROGESTERONE ON POSTMENOPAUSAL BONE LOSS [J].
RIIS, BJ ;
THOMSEN, K ;
STROM, V ;
CHRISTIANSEN, C .
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1987, 156 (01) :61-65
[18]   OSTEOPOROSIS - CAUSE AND MANAGEMENT [J].
SMITH, R .
BMJ-BRITISH MEDICAL JOURNAL, 1987, 294 (6568) :329-332
[19]   DETERMINATION OF HYDROXYPROLINE IN TISSUE AND PROTEIN SAMPLES CONTAINING SMALL PROPORTIONS OF THIS IMINO ACID [J].
WOESSNER, JF .
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1961, 93 (02) :440-&
12