POTASSIUM TITANIUM(IV) OXALATE AS A REAGENT FOR AUTOMATED PULSE POLAROGRAPHIC-DETERMINATION OF SEROMUCOIDS

A new reagent, potassium tltanium(IV) oxalate, Is reported for quantitative polarographlc determination of the seromucoid fraction of human serum. The reagent Is shown to be sensitive to seromucolds without significant Interference from the albumin or globulin content of serum, and is used for automated determination of seromucolds In a continuous-flow polarographlc system In the differential pulse operational mode. The system Is shown to operate at 60 samples/h with approximately ±0.5% precision and less than 2% carry-over for determinations In the range 1-30 mg L-1. Interferences from amino acids, vitamins, and antibiotics are shown to occur but at tolerance limits below the levels In normal serum. © 1979, American Chemical Society. All rights reserved.