INDUCTION IN VITRO OF MICROTUBULAR CRYSTALS BY VINCA ALKALOIDS

被引：134
作者：
BENSCH, KG
MARANTZ, R
WISNIEWSKI, H
SHELANSKI, M
机构：
[1] Departments of Pharmacology and Pathology, Albert Einstein College of Medicine, Bronx
来源：
SCIENCE | 1969年 / 165卷 / 3892期
关键词：
D O I：
10.1126/science.165.3892.495
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The addition of vinblastine or vincristine to solutions of pure microtubule protein or to supernatants from high-speed centrifugation of rabbit-brain homotogenates results in the formation of a finze precipitate. Examination of this precipitate by electron microscopy reveals ordered structures with areas of ladder-like configuration.
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页码：495 / +
页数：1
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