A NEW HIGH-YIELD SEMISYNTHETIC APPROACH TO (20S)-9-NH2-CAMPTOTHECIN BASED ON A SEQUENCE OF PALLADIUM-CATALYZED REDUCTIONS

被引：13

作者：

CABRI, W ^{[1
]}

CANDIANI, I ^{[1
]}

ZARINI, F ^{[1
]}

PENCO, S ^{[1
]}

BEDESCHI, A ^{[1
]}

机构：

[1] PHARMACIA,PROC RES,I-20014 NERVIANO,ITALY

来源：

TETRAHEDRON LETTERS | 1995年 / 36卷 / 50期

关键词：

D O I：

10.1016/0040-4039(95)01939-F

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new 5-step synthesis of 9-NH2-Camptothecin starting from naturalCamptothecin is described. The approach, centred on a double palladium catalysed reduction of an arylsulfonate and a nitro group, has an overall yield consistently higher than the previously reported ones.

引用

页码：9197 / 9200

页数：4

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