REVERSAL OF LEFT-RIGHT ASYMMETRY - A SITUS-INVERSUS MUTATION

被引：430

作者：

YOKOYAMA, T

COPELAND, NG

JENKINS, NA

MONTGOMERY, CA

ELDER, FFB

OVERBEEK, PA

机构：

[1] BAYLOR COLL MED, INST MOLEC GENET, DEPT CELL BIOL, HOUSTON, TX 77030 USA

[2] NCI, FREDERICK CANC RES & DEV CTR, ABL BASIC RES PROGRAM, MAMMALIAN GENET LAB, FREDERICK, MD 21702 USA

[3] BAYLOR COLL MED, INST MOLEC GENET, DEPT CELL BIOL, HOUSTON, TX 77030 USA

[4] BAYLOR COLL MED, CTR COMPARAT MED, HOUSTON, TX 77030 USA

[5] BAYLOR COLL MED, HOWARD HUGHES MED INST, HOUSTON, TX 77030 USA

[6] UNIV TEXAS, HLTH SCI CTR, DEPT PATHOL & LAB MED, HOUSTON, TX 77225 USA

来源：

SCIENCE | 1993年 / 260卷 / 5108期

关键词：

D O I：

10.1126/science.8480178

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A recessive mutation was identified in a family of transgenic mice that resulted in a reversal of left-right polarity (situs inversus) in 100 percent of the homozygous transgenic mice tested. Sequences that flanked the transgenic integration site were cloned and mapped to mouse chromosome 4, between the Tsha and Hxb loci. During early embryonic development, the direction of postimplantation turning, one of the earliest manifestations of left-right asymmetry, was reversed in homozygous transgenic embryos. This insertional mutation identifies a gene that controls embryonic turning and visceral left-right polarity.

引用

页码：679 / 682

页数：4

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