BETA-AMYLOID PROTEIN INCREASES THE VULNERABILITY OF CULTURED CORTICAL-NEURONS TO EXCITOTOXIC DAMAGE

被引：621

作者：

KOH, JY ^{[1
]}

YANG, LL ^{[1
]}

COTMAN, CW ^{[1
]}

机构：

[1] UNIV CALIF IRVINE,DEPT PSYCHOBIOL,IRVINE,CA 92717

来源：

BRAIN RESEARCH | 1990年 / 533卷 / 02期

关键词：

Alzheimer's disease; Glutamate; Kainate; N-methyl-d-aspartate; Neurodegeneration; Neurotoxicity; Plaque;

D O I：

10.1016/0006-8993(90)91355-K

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Glutamate neurotoxicity may be an underlying pathological mechanism contributing to neuronal cell loss in a variety of conditions including Alzheimer's disease (AD). In this study, we examined whether the β-amyloid protein found in the neuritic plaques of AD alters the susceptibility of neurons to excitotoxic damage. While mature cortical neurons exposed to β-amyloid protein for 2-4 days did not appear to be damaged, their vulnerability to low-intesity exposure to glutamate, N-methyl-d-aspartate, and kainate increased, suggesting that this mechanism may contribute to the neurodegeneration seen in AD. © 1990.

引用

页码：315 / 320

页数：6

共 30 条

[1] LOCALIZATION OF VOLTAGE-SENSITIVE CALCIUM CHANNELS ALONG DEVELOPING NEURITES - THEIR POSSIBLE ROLE IN REGULATING NEURITE ELONGATION [J].