DOPAMINE RECEPTOR ABNORMALITIES IN THE STRIATUM AND PALLIDUM IN TARDIVE-DYSKINESIA - A POST-MORTEM STUDY

被引：15
作者：
REYNOLDS, GP
BROWN, JE
MCCALL, JC
MACKAY, AVP
机构：
[1] UNIV NOTTINGHAM,SCH MED,DEPT PATHOL,NOTTINGHAM NG7 2RD,ENGLAND
[2] ARGYLL & BUTE HOSP,LOCHGILPHEAD,ARGYLL,SCOTLAND
来源：
JOURNAL OF NEURAL TRANSMISSION-GENERAL SECTION | 1992年 / 87卷 / 03期
基金：
英国惠康基金;
关键词：
SCHIZOPHRENIA; TARDIVE DYSKINESIA; NEUROLEPTICS; HUMAN BRAIN; DOPAMINE RECEPTORS;
D O I：
10.1007/BF01245368
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Dopamine D1 and D2 receptors were determined in brain tissue taken post mortem from schizophrenic patients previously known to have had tardive dyskinesia and yet who had not received neuroleptic drug treatment for over one year prior to death. In comparison with age-matched control subjects, diminished D2 receptor density was observed in striatal regions, while these receptors appeared to be increased in the pallidum, an area of the brain particularly implicated in the production of dyskinesias. D1 receptors showed similar tendencies to lower numbers in the striatum in tardive dyskinesia.
引用
收藏
页码：225 / 230
页数：6
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