HALOPERIDOL INCREASES DOPAC IN THE SUBSTANTIA NIGRA BUT NOT IN THE VENTRAL TEGMENTAL AREA

被引：8

作者：

ARGIOLAS, A ^{[1
]}

FADDA, F ^{[1
]}

MELIS, MR ^{[1
]}

GESSA, GL ^{[1
]}

机构：

[1] UNIV CAGLIARI,INST PHYSIOL,I-09100 CAGLIARI,ITALY

来源：

LIFE SCIENCES | 1979年 / 24卷 / 24期

关键词：

D O I：

10.1016/0024-3205(79)90105-X

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Haloperidol (0.1 to 0.5 mg/kg) caused a dose related increase in DOPAC content both in the substantia nigra (pars compacta + pars reticulata) (by 27 to 134%) and in the caudate nucleus (by 127 to 252%). On the contrary even 5 mg/kg of haloperidol failed to modify DOPAC level in the ventral tegmental area. The results indicate that DA cells in ventral tegmental area differ from those in the substantia nigra not only on anatomical grounds but also on a functional point of view. © 1979.

引用

页码：2279 / 2284

页数：6

共 23 条

[1] RADIOENZYMATIC METHOD TO MEASURE PICOGRAM AMOUNTS OF DOPAMINE AND 3,4-DIHYDROXYPHENYLACETIC ACID (DOPAC) IN SMALL SAMPLES OF BRAIN-TISSUE [J].