ORAL CONTRACEPTIVES - LONG-TERM USE PRODUCES FINE STRUCTURAL CHANGES IN LIVER MITOCHONDRIA

被引:88
作者
PEREZ, V
GOROSDISCH, S
DEMARTIR.J
NICHOLOS.R
DIPAOLA, G
机构
[1] Instituto Nacional de la Salud, Haedo, Buenos Aires
[2] Facultad de Medicina, Universidad Nacional de Buenos Aires
关键词
D O I
10.1126/science.165.3895.805
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Liver biopsies from two groups of women receiving oral contraceptives from 1 to 6 months and from 12 to 30 months, respectively, were examined by electron microscopy. The fine structure of the liver cells from the first group appeared normal, except for an increase in the amount of smooth endoplasmic reticulum. In the second group, however, there were many cases with striking changes-altered shape, increase in size, and presence of paracrystalline inclusions-in the mitochondria. No significant correlation between mitochondrial changes and alterations in liver function was detected.
引用
收藏
页码:805 / +
页数:1
相关论文
共 18 条
[1]  
ADLERCREUTZ H, 1964, BMJ-BRIT MED J, V2, P1133, DOI 10.1136/bmj.2.5417.1133
[2]  
HAUST MD, 1968, EXP MOL PATHOL, V8, P123
[3]   DEGENERESCENCE MYELINIQUE DES MITOCHONDRIES DE FOIE HUMAIN DANS UN EPITHELIOMA DU CHOLEDOQUE ET UN ICTERE VIRAL - ETUDE AU MICROSCOPE ELECTRONIQUE [J].
JEZEQUEL, AM .
JOURNAL OF ULTRASTRUCTURE RESEARCH, 1959, 3 (02) :210-215
[4]   DEGENERATION OF LIVER MITOCHONDRIA IN RATS AFTER PROLONGED ALCOHOL CONSUMPTION [J].
KIESSLING, KH ;
TOBE, U .
EXPERIMENTAL CELL RESEARCH, 1964, 33 (1-2) :350-&
[5]  
LAGUENS RUBEN, 1963, EXPTL AND MOLECULAR PATHOL, V2, P203, DOI 10.1016/0014-4800(63)90035-2
[6]   IMPROVEMENTS IN EPOXY RESIN EMBEDDING METHODS [J].
LUFT, JH .
JOURNAL OF BIOPHYSICAL AND BIOCHEMICAL CYTOLOGY, 1961, 9 (02) :409-&
[7]  
MCGUIRE JS, 1960, J BIOL CHEM, V235, P3112
[8]   FILAMENTOUS INCLUSIONS IN MATRIX OF MITOCHONDRIA FROM HUMAN LIVERS [J].
MUGNAINI, E .
JOURNAL OF ULTRASTRUCTURE RESEARCH, 1964, 11 (5-6) :525-&
[9]  
ORELLANAALCALDE JM, 1966, LANCET, V2, P1278
[10]   A STUDY OF FIXATION FOR ELECTRON MICROSCOPY [J].
PALADE, GE .
JOURNAL OF EXPERIMENTAL MEDICINE, 1952, 95 (03) :285-&