EFFECTS OF L-GLUTAMIC ACID AND KAINIC ACID ON CENTRAL CARDIOVASCULAR CONTROL

被引：19
作者：
CHELLY, J
KOUYOUMDJIAN, JC
MOUILLE, P
HUCHET, AM
SCHMITT, H
机构：
[1] INSERM,FRA 38,F-75005 PARIS,FRANCE
[2] UNIV PARIS 12,CTR HOSP UNIV HENRI MONDOR,DEPT BIOCHIM,F-94010 CRETEIL,FRANCE
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 1979年 / 60卷 / 01期
关键词：
Blood pressure; Central control; Kainic acid; L-Glutamic acid;
D O I：
10.1016/0014-2999(79)90055-4
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
L-Glutamine acid and kainic acid injected int o the cisterna magna of dogs, produced a dose-dependent increase in blood pressure and a decrease in heart rate. In contrast, intravenous injection of both compounds was ineeffective. The hypertension was probably due to an increase in sympathetic tone as guanethidine prevented the rise in blood pressure induced by central administration of L-glutamic acid and kainic acid. Kainic acid was 1000 fold more potent than L-glutamic acid. © 1979.
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页码：91 / 94
页数：4
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