EFFECT OF HYDROCORTISONE ON SUPEROXIDE PRODUCTION BY LEUKOCYTES

被引：34

作者：

FUENFER, MM ^{[1
]}

CARR, EA ^{[1
]}

POLK, HC ^{[1
]}

机构：

[1] UNIV LOUISVILLE,HLTH SCI CTR,SCH MED,DEPT PHARMACOL,LOUISVILLE,KY 40232

来源：

JOURNAL OF SURGICAL RESEARCH | 1979年 / 27卷 / 01期

关键词：

D O I：

10.1016/0022-4804(79)90106-9

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Corticosteroids have been shown to significantly depress intracellular bactericidal pathways. Formation of superoxide anion (O2-) is thought to be an important intermediary in this process. We have demonstrated that actively phagocytizing PMNs generate significantly diminished levels of O2- in the presence of hydrocortisone sodium succinate. © 1979.

引用

页码：29 / 35

页数：7

共 28 条

[21] SINGLET OXYGEN - UNIQUE MICROBICIDAL AGENT IN CELLS [J].

MAUGH, TH .

SCIENCE, 1973, 182 (4107) :44-45

[22] FAILURE OF NITRO BLUE TETRAZOLIUM REDUCTION IN PHAGOCYTIC VACUOLES OF LEUKOCYTES IN CHRONIC GRANULOMATOUS DISEASE [J].

NATHAN, DG ;

BAEHNER, RL ;

WEAVER, DK .

JOURNAL OF CLINICAL INVESTIGATION, 1969, 48 (10) :1895-&

[23] CORTICOSTEROIDS, SERUM, AND PHAGOCYTOSIS - IN-VITRO AND IN-VIVO STUDIES [J].

OLDS, JW ;

REED, WP ;

EBERLE, B ;

KISCH, AL .

INFECTION AND IMMUNITY, 1974, 9 (03) :524-529

[24]

PARK BH, 1968, LANCET, V2, P532

[25] PHYSIOLOGICAL DISPOSITION AND METABOLIC FATE OF HYDROCORTISONE IN MAN [J].

PETERSON, RE ;

WYNGAARDEN, JB ;

GUERRA, SL ;

BRODIE, BB ;

BUNIM, JJ .

JOURNAL OF CLINICAL INVESTIGATION, 1955, 34 (12) :1779-1794

[26]

SBARRA AJ, 1972, J RETICULOENDOTH SOC, V12, P109

[27] EFFECT OF CORTICOSTEROIDS ON HUMAN MONOCYTE IGG AND COMPLEMENT RECEPTORS [J].

SCHREIBER, AD ;

PARSONS, J ;

MCDERMOTT, P ;

COOPER, RA .

JOURNAL OF CLINICAL INVESTIGATION, 1975, 56 (05) :1189-1197

[28] INHIBITION OF THE ENZYMIC OXIDATION OF DPNH BY STEROID HORMONES [J].

YIELDING, KL ;

TOMKINS, GM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1959, 45 (12) :1730-1739

← 1 2 3 →