EFFECT OF HYDROCORTISONE ON SUPEROXIDE PRODUCTION BY LEUKOCYTES

被引：34

作者：

FUENFER, MM ^{[1
]}

CARR, EA ^{[1
]}

POLK, HC ^{[1
]}

机构：

[1] UNIV LOUISVILLE,HLTH SCI CTR,SCH MED,DEPT PHARMACOL,LOUISVILLE,KY 40232

来源：

JOURNAL OF SURGICAL RESEARCH | 1979年 / 27卷 / 01期

关键词：

D O I：

10.1016/0022-4804(79)90106-9

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Corticosteroids have been shown to significantly depress intracellular bactericidal pathways. Formation of superoxide anion (O2-) is thought to be an important intermediary in this process. We have demonstrated that actively phagocytizing PMNs generate significantly diminished levels of O2- in the presence of hydrocortisone sodium succinate. © 1979.

引用

页码：29 / 35

页数：7

共 28 条

[1] PYRIDINE NUCLEOTIDE-DEPENDENT SUPEROXIDE PRODUCTION BY A CELL-FREE SYSTEM FROM HUMAN GRANULOCYTES [J].

BABIOR, BM ;

CURNUTTE, JT ;

KIPNES, RS .

JOURNAL OF CLINICAL INVESTIGATION, 1975, 56 (04) :1035-1042

[2] BIOLOGICAL DEFENSE MECHANISMS - PRODUCTION BY LEUKOCYTES OF SUPEROXIDE A POTENTIAL BACTERICIDAL AGENT [J].

BABIOR, BM ;

KIPNES, RS ;

CURNUTTE, JT .

JOURNAL OF CLINICAL INVESTIGATION, 1973, 52 (03) :741-744

[3] DEFICIENCY OF REDUCED NICOTINAMIDE-ADENINE DINUCLEOTIDE OXIDASE IN CHRONIC GRANULOMATOUS DISEASE [J].

BAEHNER, RL ;

KARNOVSKY, ML .

SCIENCE, 1968, 162 (3859) :1277-+

[4]

BAEHNER RL, 1974, BLOOD, V44, P926

[5]

Brothers J R, 1973, Surg Forum, V24, P30

[6] EFFECTS OF CORTICOSTEROIDS ON IMMUNITY IN MAN .1. DECREASED SERUM IGG CONCENTRATION CAUSED BY 3 OR 5 DAYS OF HIGH DOSES OF METHYLPREDNISOLONE [J].

BUTLER, WT ;

ROSSEN, RD .

JOURNAL OF CLINICAL INVESTIGATION, 1973, 52 (10) :2629-2640

[7]

CHRETIEN JH, 1972, J RETICULOENDOTH SOC, V11, P358

[8] SUPPRESSED REDUCTION OF NITROBLUE TETRAZOLIUM BY POLYMORPHONUCLEAR NEUTROPHILS FROM PATIENTS RECEIVING STEROIDS [J].

CHRETIEN, JH ;

GARAGUSI, VF .

EXPERIENTIA, 1971, 27 (11) :1343-&

[9]

COOPER MR, 1972, P SOC EXP BIOL MED, V141, P986

[10] DEFECTIVE SUPEROXIDE PRODUCTION BY GRANULOCYTES FROM PATIENTS WITH CHRONIC GRANULOMATOUS DISEASE [J].

CURNUTTE, JT ;

WHITTEN, DM ;

BABIOR, BM .

NEW ENGLAND JOURNAL OF MEDICINE, 1974, 290 (11) :593-597

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