EFFECT OF HYDROCORTISONE ON SUPEROXIDE PRODUCTION BY LEUKOCYTES

被引:34
作者
FUENFER, MM [1 ]
CARR, EA [1 ]
POLK, HC [1 ]
机构
[1] UNIV LOUISVILLE,HLTH SCI CTR,SCH MED,DEPT PHARMACOL,LOUISVILLE,KY 40232
关键词
D O I
10.1016/0022-4804(79)90106-9
中图分类号
R61 [外科手术学];
学科分类号
摘要
Corticosteroids have been shown to significantly depress intracellular bactericidal pathways. Formation of superoxide anion (O2-) is thought to be an important intermediary in this process. We have demonstrated that actively phagocytizing PMNs generate significantly diminished levels of O2- in the presence of hydrocortisone sodium succinate. © 1979.
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页码:29 / 35
页数:7
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