CLONING OF CDNA AND GENOMIC DNA ENCODING HUMAN TYPE-XVIII COLLAGEN AND LOCALIZATION OF THE ALPHA-1(XVIII) COLLAGEN GENE TO MOUSE CHROMOSOME-10 AND HUMAN-CHROMOSOME-21

被引：112
作者：
OH, SP
WARMAN, ML
SELDIN, MF
CHENG, SD
KNOLL, JHM
TIMMONS, S
OLSEN, BR
机构：
[1] HARVARD UNIV,SCH MED,DEPT CELLULAR BIOL,BOSTON,MA 02115
[2] DUKE UNIV,MED CTR,DEPT MED & MICROBIOL,DURHAM,NC 27710
[3] HARVARD UNIV,CHILDRENS HOSP,SCH MED,DIV GENET,BOSTON,MA 02115
[4] HARVARD UNIV,BETH ISRAEL HOSP,SCH MED,DEPT PATHOL,BOSTON,MA 02115
来源：
GENOMICS | 1994年 / 19卷 / 03期
关键词：
D O I：
10.1006/geno.1994.1098
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Types XV and XVIII collagen belong to a unique and novel subclass of the collagen superfamily for which we have proposed the name the MULTIPLEXIN family. Members of this class contain polypeptides with multiple triple-helical domains separated and flanked by non-triple-helical regions. In this paper, we report the isolation of human cDNAs and genomic DNAs encoding the alpha 1(XVIII) collagen chain. Utilizing a genomic clone as probe, we have mapped the COL18A1 gene to chromosome 21q22.3 by fluorescence in situ hybridization. In addition, using an interspecific backcross panel, we have shown that the murine Col18al locus is on chromosome 10, close to the loci for Col6a1 and Col6a2. (C) 1994 Academic Press, Inc.
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页码：494 / 499
页数：6
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