BRAIN-ASSOCIATED GLYCOPROTEINS EXPRESSED IN BOVINE HEART PURKINJE-FIBERS

被引:1
作者
BERGLUND, E
GROVE, BK
THORNELL, LE
STIGBRAND, T
机构
[1] UMEA UNIV,DEPT PHYSIOL CHEM,S-90187 UMEA,SWEDEN
[2] UMEA UNIV,DEPT ANAT,S-90187 UMEA,SWEDEN
关键词
D O I
10.1007/BF00315738
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The Purkinje fibres of bovine heart were investigated immunohistochemically by use of monoclonal antibodies with specificity against the glycoproteins Thy-1 and Gp120, expressed in human brain. The existence and expression in bovine tissues (brain and thymus) of antigens displaying similar properties and immunochemical crossreactivity with monoclonal antibodies against the human antigens were confirmed. Both these antigens, as identified by use of anti Thy-1 and anti-Gp120 monoclonal antibodies were found to be associated with the membranes of the impulse conduction system. The presence of the antigens was seen in areas facing other conduction cells. No parts of the cells facing the basal membrane of the fibres were stained. The continuous staining between the cells was different from that of desmosome related proteins. These findings may have physiological and functional implications and are interesting in relation to recent evidences suggesting that the conduction tissue might be a derivative of the neural crest.
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页码:435 / 440
页数:6
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