Scientific Opinion on the scrapie situation in the EU after 10 years of monitoring and control in sheep and goats EFSA Panel on Biological Hazards (BIOHAZ)

被引：19

作者：

Andreoletti, Olivier ^{[1
]}

Baggesen, Dorte Lau ^{[1
]}

Bolton, Declan ^{[1
]}

Butaye, Patrick ^{[1
]}

Cook, Paul ^{[1
]}

Davies, Robert ^{[1
]}

Escamez, Pablo S. Fernandez ^{[1
]}

Griffin, John ^{[1
]}

Hald, Tine ^{[1
]}

Havelaar, Arie ^{[1
]}

Koutsoumanis, Kostas ^{[1
]}

Lindqvist, Roland ^{[1
]}

McLauchlin, James ^{[1
]}

Nesbakken, Truls ^{[1
]}

Maradona, Miguel Prieto ^{[1
]}

Ricci, Antonia ^{[1
]}

Ru, Giuseppe ^{[1
]}

Sanaa, Moez ^{[1
]}

Simmons, Marion ^{[1
]}

Sofos, John ^{[1
]}

Threlfall, John ^{[1
]}

机构：

[1] European Food Safety Author, Parma, Italy

来源：

EFSA JOURNAL | 2014年 / 12卷 / 07期

关键词：

Atypical scrapie; breeding programme; Classical scrapie; goat; sheep; surveillance;

D O I：

10.2903/j.efsa.2014.3781

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

To assess the effectiveness of the strategies implemented in the European Union (EU) to control Classical scrapie (CS), epidemiological data have been compared in the context of the efforts in terms of control measures applied over time. Official EU surveillance data and results from questionnaire surveys of EU Member States (MSs) have been used along with case studies. A spatio-temporal description of the occurrence of small ruminants TSEs in MSs in the period 2002-2012 is provided, with a particular focus on CS in sheep. Based on information collected from MSs, the potential effectiveness of breeding programmes for resistance to CS (BPCS) in the dissemination of resistance into the general sheep population has been assessed for those countries for which the CS trend analysis has been performed. CS in sheep was reported in 17 MSs (average prevalence: 8.7 cases/10 000 tests), with heterogeneous trends and geographical distribution: among the 13 countries reporting a consistent number of cases, the trend analysis shows a statistically significant decreasing trend only for six of them. Variations in the implementation of genetic and non-genetic measures for the control of CS may explain the failure to improve the disease situation in the remaining seven MSs. At a national level, a reduction in CS seems to be linked to better-achieving BP-CSs. Control options applied to CS in sheep and goats indicate that a CS eradication policy that relies solely on the detection of infected flocks by post-mortem testing and subsequent depopulation would be unlikely to succeed. A minimum frequency of the ARR allele in a sheep population above which CS may be expected to fade-out could be estimated for each specific national sheep population. Recommendations for additional/alternative measures to control CS in sheep and goats are formulated. (C) European Food Safety Authority, 2014

引用

页数：155

共 155 条

[1] Resistance to classical scrapie in experimentally challenged goats carrying mutation K222 of the prion protein gene [J].

Acutis, Pier Luigi ;

Martucci, Francesca ;

D'Angelo, Antonio ;

Peletto, Simone ;

Colussi, Silvia ;

Maurella, Cristiana ;

Porcario, Chiara ;

Iulini, Barbara ;

Mazza, Maria ;

Dell'Atti, Luana ;

Zuccon, Fabio ;

Corona, Cristiano ;

Martinelli, Nicola ;

Casalone, Cristina ;

Caramelli, Maria ;

Lombardi, Guerino .

VETERINARY RESEARCH, 2012, 43

[2] Identification of prion protein gene polymorphisms in goats from Italian scrapie outbreaks [J].

Acutis, PL ;

Bossers, A ;

Priem, J ;

Riina, MV ;

Peletto, S ;

Mazza, M ;

Casalone, C ;

Forloni, G ;

Ru, G ;

Caramelli, M .

JOURNAL OF GENERAL VIROLOGY, 2006, 87 :1029-1033

[3]

ANDERSON R M, 1991

[4] Phenotyping of protein-prion (PrPsc)-accumulating cells in lymphoid and neural tissues of naturally scrapie-affected sheep by double-labeling immunohistochemistry [J].

Andréoletti, O ;

Berthon, P ;

Levavasseur, E ;

Marc, D ;

Lantier, F ;

Monks, E ;

Elsen, JM ;

Schelcher, F .

JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY, 2002, 50 (10) :1357-1370

[5] Early accumulation of PrPSc in gut-associated lymphoid and nervous tissues of susceptible sheep from a Romanov flock with natural scrapie [J].

Andréoletti, O ;

Berthon, P ;

Marc, D ;

Sarradin, P ;

Grosclaude, J ;

van Keulen, L ;

Schelcher, F ;

Elsen, JM ;

Lantier, F .

JOURNAL OF GENERAL VIROLOGY, 2000, 81 :3115-3126

[6] PrPSc accumulation in myocytes from sheep incubating natural scrapie [J].

Andréoletti, O ;

Simon, S ;

Lacroux, C ;

Morel, N ;

Tabouret, G ;

Chabert, A ;

Lugan, S ;

Corbière, F ;

Ferré, P ;

Foucras, G ;

Laude, H ;

Eychenne, F ;

Grassi, J ;

Schelcher, F .

NATURE MEDICINE, 2004, 10 (06) :591-593

[7] PrPSc accumulation in placentas of ewes exposed to natural scrapie:: influence of foetal PrP genotype and effect on ewe-to-lamb transmission [J].

Andréoletti, O ;

Lacroux, C ;

Chabert, A ;

Monnereau, L ;

Tabouret, G ;

Lantier, F ;

Berthon, P ;

Eychenne, F ;

Lafond-Benestad, S ;

Elsen, JM ;

Schelcher, F .

JOURNAL OF GENERAL VIROLOGY, 2002, 83 :2607-2616

[8] Scientific Opinion on the risk of transmission of classical scrapie via in vivo derived embryo transfer in ovine animals EFSA Panel on Biological Hazards [J].

Andreoletti, Olivier ;

Baggesen, Dorte Lau ;

Bolton, Declan ;

Butaye, Patrick ;

Cook, Paul ;

Davies, Robert ;

Escamez, Pablo S. Fernandez ;

Griffin, John ;

Hald, Tine ;

Havelaar, Arie ;

Koutsoumanis, Kostas ;

Lindqvist, Roland ;

McLauchlin, James ;

Nesbakken, Truls ;

Maradona, Miguel Prieto ;

Ricci, Antonia ;

Ru, Giuseppe ;

Sanaa, Moez ;

Simmons, Marion ;

Sofos, John ;

Threlfall, John .

EFSA JOURNAL, 2013, 11 (02)

[9] Scientific Opinion on Analytical sensitivity of approved TSE rapid tests EFSA Panel on Biological Hazards (BIOHAZ) [J].

Andreoletti, Olivier ;

Budka, Herbert ;

Buncic, Sava ;

Collins, John D. ;

Griffin, John ;

Hald, Tine ;

Havelaar, Arie Hendrik ;

Hope, James ;

Klein, Guenter ;

McLauchlin, James ;

Messens, Winy ;

Mueller-Graf, Christine ;

Nguyen-The, Christophe ;

Noerrung, Birgit ;

Peixe, Luisa ;

Maradona, Miguel Prieto ;

Ricci, Antonia ;

Sofos, John ;

Threlfall, John ;

Vagsholm, Ivar ;

Vanopdenbosch, Emmanuel .

EFSA JOURNAL, 2009, 7 (12)

[10] Atypical/Nor98 Scrapie Infectivity in Sheep Peripheral Tissues [J].

Andreoletti, Olivier ;

Orge, Leonor ;

Benestad, Sylvie L. ;

Beringue, Vincent ;

Litaise, Claire ;

Simon, Stephanie ;

Le Dur, Annick ;

Laude, Hubert ;

Simmons, Hugh ;

Lugan, Severine ;

Corbiere, Fabien ;

Costes, Pierrette ;

Morel, Nathalie ;

Schelcher, Francois ;

Lacroux, Caroline .

PLOS PATHOGENS, 2011, 7 (02)

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