PERSPECTIVES AND FUTURE-DIRECTIONS

被引：0

作者：

GRUBB, R ^{[1
]}

机构：

[1] LUND UNIV, DEPT MED MICROBIOL, S-22100 LUND, SWEDEN

来源：

EXPERIMENTAL AND CLINICAL IMMUNOGENETICS | 1995年 / 12卷 / 03期

关键词：

AIDS; ALLOTYPES; GENE TRANSFER; HISTORY OF IMMUNOGENETICS; RHEUMATOID ARTHRITIS; TRANSDUCTION BY HERPESVIRUSES;

D O I：

暂无

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

An outline of the history of immunogenetics is presented. The usefulness of the Rh, KLA and Gm systems in disease prediction and prevention will increase with our capacity precisely to relate polymorphic variants to particular functions and pathophysiological events. Alloimmunization to Gm markers is common in rheumatoid arthritis, an allegedly autoimmune disease. This paradox and the paradox of nonnominal allotypes, disobeying Mendelian rules, are resolved by the interpretation that herpesviruses may transfer nonself polymorphic genes. Transduction of such genes may be important also in AIDS pathogenesis.

引用

页码：217 / 221

页数：5

共 26 条

[1] HUMAN CYTOMEGALO-VIRUS ENCODES A GLYCOPROTEIN HOMOLOGOUS TO MHC CLASS-I ANTIGENS [J].