ESCAPE OF RED-BLOOD-CELLS THROUGH GAPS IN GLOMERULAR-BASEMENT-MEMBRANE IN A PATIENT WITH MIXED CONNECTIVE-TISSUE DISEASE

Hematuria in patients with glomerulonephritis seems to result from the passage of red blood cells through anatomical gaps in the glomerular basement membrane, However, such morphological evidence has rarely been demonstrated. A patient with mixed connective tissue disease associated with membranous glomerulonephritis is described in whom the renal biopsy specimen showed an escape of red blood cells through a gag in the basement membrane, These findings support the morphological basis of hematuria in glomerulonephritis.