CHEMOATTRACTION OF HUMAN BLOOD T-LYMPHOCYTES BY INTERLEUKIN-15

被引：229
|
作者：
WILKINSON, PC
LIEW, FY
机构：
[1] Department of Immunology, University of Glasgow, Western Infirmary, Glasgow
来源：
JOURNAL OF EXPERIMENTAL MEDICINE | 1995年 / 181卷 / 03期
基金：
英国惠康基金;
关键词：
D O I：
10.1084/jem.181.3.1255
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Recombinant interleukin (IL)-15, derived from a simian kidney epithelial cell line, is a chemoattractant for human blood T lymphocytes judged by its ability to increase the proportion of cells in polarized morphology, to stimulate invasion of collagen gels containing IL-15, and to increase the proportion of locomotor cells observed by time-lapse videorecording. The ability of lymphocytes to respond was partly, but not completely, inhibited by pretreatment with anti-IL-2 receptor beta-chain. The activity of IL-15 was completely abolished by preincubation with aIL-15 but unaffected by preincubation with aIL-2. No response of monocytes, neutrophils, or B lymphocytes to IL-15 was observed.
引用
收藏
页码：1255 / 1259
页数：5
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