THE TEMPERATURE-COMPOSITION PHASE-DIAGRAM AND MESOPHASE STRUCTURE CHARACTERIZATION OF MONOPENTADECENOIN IN WATER

被引：49
作者：
BRIGGS, J [1 ]
CAFFREY, M [1 ]
机构：
[1] OHIO STATE UNIV,DEPT CHEM,COLUMBUS,OH 43210
来源：
BIOPHYSICAL JOURNAL | 1994年 / 67卷 / 04期
关键词：
D O I：
10.1016/S0006-3495(94)80632-0
中图分类号：
Q6 [生物物理学];
学科分类号：
071011 ;
摘要：
The temperature-composition phase diagram of monopentadecenoin, a monoacylglycerol with a cis monounsaturated fatty acid 15 carbon atoms long (C15:1c10) in water was constructed using x-ray diffraction. Low- and wide-angle diffraction patterns were collected from samples of fixed hydration as a function of temperature in the heating direction on x-ray-sensitive film. The temperature and hydration ranges investigated were 0-104 degrees C and 0-60% (w/w) water, respectively. The phases identified in the system include the lamellar crystalline phase, the lamellar liquid crystalline phase, the fluid isotropic phase, and two inverted cubic phases belonging to space groups Ia3d (Q(230)) and Pn3m (Q(244)). Particular attention has been devoted to the issues of phase equilibrium, phase boundary verification, and structure characterization. The phase diagrams of monopentadecenoin, monomyristolein (C14:1c9), and monoolein (C18:1c9) are compared, and the impact of molecular structure on mesophase stability and structure is discussed.
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页码：1594 / 1602
页数：9
相关论文
共 28 条
[11]  
HOGAN JL, 1989, THESIS U SOUTHAMPTON
[12]   A CUBIC STRUCTURE CONSISTING OF A LIPID BILAYER FORMING AN INFINITE PERIODIC MINIMUM SURFACE OF THE GYROID TYPE IN THE GLYCEROLMONOOLEATE-WATER SYSTEM [J].
HYDE, ST ;
ANDERSSON, S ;
ERICSSON, B ;
LARSSON, K .
ZEITSCHRIFT FUR KRISTALLOGRAPHIE, 1984, 168 (1-4) :213-219
[13]   MODULATION OF DOLICHYL-PHOSPHOMANNOSE SYNTHASE ACTIVITY BY CHANGES IN THE LIPID ENVIRONMENT OF THE ENZYME [J].
JENSEN, JW ;
SCHUTZBACH, JS .
BIOCHEMISTRY, 1988, 27 (17) :6315-6320
[14]   SPECTRA AND PHYSICAL-PROPERTIES OF LIPOSOMES AND MONOLAYERS OF POLYMERIZABLE PHOSPHOLIPIDS CONTAINING DIACETYLENE GROUPS IN ONE OR BOTH ACYL CHAINS [J].
JOHNSTON, DS ;
MCLEAN, LR ;
WHITTAM, MA ;
CLARK, AD ;
CHAPMAN, D .
BIOCHEMISTRY, 1983, 22 (13) :3194-3202
[15]  
Kates M., 1986, TECHNIQUES LIPIDOLOG
[16]   PHASES AND PHASE-TRANSITIONS OF THE HYDRATED PHOSPHATIDYLETHANOLAMINES [J].
KOYNOVA, R ;
CAFFREY, M .
CHEMISTRY AND PHYSICS OF LIPIDS, 1994, 69 (01) :1-34
[17]   NEW METHODS OF DRUG DELIVERY [J].
LANGER, R .
SCIENCE, 1990, 249 (4976) :1527-1533
[18]   GELATION OF LIPOSOME INTERIOR - A NOVEL METHOD FOR DRUG ENCAPSULATION [J].
LASIC, DD ;
FREDERIK, PM ;
STUART, MCA ;
BARENHOLZ, Y ;
MCINTOSH, TJ .
FEBS LETTERS, 1992, 312 (2-3) :255-258
[19]   CUBIC PHASES AND ISOTROPIC STRUCTURES FORMED BY MEMBRANE-LIPIDS - POSSIBLE BIOLOGICAL RELEVANCE [J].
LINDBLOM, G ;
RILFORS, L .
BIOCHIMICA ET BIOPHYSICA ACTA, 1989, 988 (02) :221-256
[20]   CUBIC PHASES OF LIPID-CONTAINING SYSTEMS - STRUCTURE-ANALYSIS AND BIOLOGICAL IMPLICATIONS [J].
MARIANI, P ;
LUZZATI, V ;
DELACROIX, H .
JOURNAL OF MOLECULAR BIOLOGY, 1988, 204 (01) :165-188
123