A review about biomarkers for the investigation of vascular function and impairment in diabetes mellitus

被引：24
作者：
Derosa, Giuseppe [1 ,2 ]
Maffioli, Pamela [3 ]
机构：
[1] Univ Pavia, Dept Internal Med & Therapeut, Ctr Diabet & Metab Dis, Ple C Golgi 2, I-27100 Pavia, Italy
[2] Fdn IRCCS Policlin S Matteo, Ple C Golgi 2, I-27100 Pavia, Italy
[3] Univ Pavia, Sch Expt Med, Pavia, Italy
来源：
VASCULAR HEALTH AND RISK MANAGEMENT | 2016年 / 12卷
关键词：
biomarkers; vascular function; type 2 diabetes mellitus;
D O I：
10.2147/VHRM.S64460
中图分类号：
R6 [外科学];
学科分类号：
1002 ; 100210 ;
摘要：
The aim of this review was to analyze the main biomarkers of vascular function and impairment in patients with type 2 diabetes. Medline, SCOPUS, Web of Science, and Google Scholar databases were searched. We concluded that proatherogenic adhesion molecules (soluble intercellular adhesion molecule-1, soluble vascular adhesion molecule-1, and soluble E selectin) and inflammatory cytokines (high-sensitivity C-reactive protein, interleukin-6, and tumor necrosis factor-alpha) were elevated in type 2 diabetes mellitus. Their increased expression and release contribute to the accelerated atherogenesis typical of these patients. For these reasons, the early identification of high levels of these biomarkers will help to establish new strategies to reduce cardiovascular complications.
引用
收藏
页码：415 / 419
页数：5
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