PENICILLAMINE-INDUCED PSEUDO-PSEUDOXANTHOMA ELASTICUM IN A PATIENT WITH RHEUMATOID-ARTHRITIS

被引：20
作者：
BURGE, S
RYAN, T
机构：
来源：
CLINICAL AND EXPERIMENTAL DERMATOLOGY | 1988年 / 13卷 / 04期
关键词：
D O I：
10.1111/j.1365-2230.1988.tb00693.x
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
Penicillamine is a heavy metal chelator which is used in the treatment of Wilson''s disease, cystinuria, rheumatoid arthritis and scleroderma. The cutaneous side-effects of prolonged, high dose (1-2 g/day) treatment include skin fragility, elatosis perforans serpiginosa (EPS), cutis laxa and rarely pseudoxanthoma elasticum-like changes. We describe the clinical and post-mortem findings in a patient who developed pseudo-pseudoxanthoma elasticum and multi-system penicillamine-induced elastosis while taking D-penicillamine (750 mg/day). There are no previous reports of penicillamine-induced elastic tissue damage in a patient with rheumatoid arthritis.
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页码：255 / 258
页数：4
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