High specific immune response to a bivalent anti-HPV vaccine in HIV-1-infected men in Sao Paulo, Brazil

被引:8
作者
Fontes, Adriele [1 ,2 ]
Andreoli, Maria Antonieta [4 ]
Villa, Luisa Lina [5 ]
Assone, Tatiane [1 ,2 ]
Gaester, Karen [1 ,2 ]
Fonseca, Luiz A. M. [3 ]
Duarte, Alberto J. S. [1 ]
Casseb, Jorge [1 ,2 ]
机构
[1] Univ Sao Paulo, Fac Med, Dept Dermatol, Lab Dermatol Imunodeficiencias, Sao Paulo, Brazil
[2] Inst Med Trop Sao Paulo, Sao Paulo, SP, Brazil
[3] Univ Sao Paulo, Fac Med, Dept Prevent Med, Sao Paulo, Brazil
[4] Santa Casa Sao Paulo, HPV Inst, Sao Paulo, Brazil
[5] Univ Sao Paulo, Fac Med, Dept Radiol & Oncol, Sao Paulo, Brazil
来源
PAPILLOMAVIRUS RESEARCH | 2016年 / 2卷
基金
巴西圣保罗研究基金会;
关键词
HIV-1; HPV; Vaccine; Immune response;
D O I
10.1016/j.pvr.2016.01.001
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Introduction: Infection with Human papillomavirus (HPV) has been reported as one of the most prevalent agent sexually transmitted diseases, but its true prevalence in men is not precisely known, mainly due to the near absence of symptoms. Moreover, few studies evaluating the post-vaccination immune response have been performed to date in men, hence the hypotheses tested in this study can be important to enable a better understanding of both the immunopathogenesis and the response to vaccination in HIV-infected patients, and to help in the elaboration of strategies of vaccination against HPV in the HIV-infected population. Objectives: To analyze the specific response to antigens of HPV vaccine in HIV-infected men. Methods: A total of 25 HIV-infected male patients who met the inclusion criteria during the data collection period were vaccinated; however, six (30%) had anti-HPV at baseline, and were not considered further in the analysis. Therefore, 19 HIV-infected individuals were included in the study, along with five healthy, HPV-seronegative controls. Results: Patients infected with HIV-1 were subdivided into two groups, A and B, according to their T CD4 cells count at the time of vaccination, namely: Group A: CD4 > 500; Group B: CD4 < 500. The proportion of seroconversion after immunization with three doses of a bivalent anti-HPV vaccine was 92%. Conclusion: HIV-infected patients as well as HIV negative controls responded to anti-HPV vaccination, regardless of their T CD4 cells count and HIV plasma viral load. These results demonstrate that anti-HPV immunization in HIV-infected males is effective and should be encouraged, thus helping to decrease the risk of infection, mortality and morbidity of diseases associated with HPV in men. (C) 2016 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommon.org/licenses/by-nc-nd/4.0/).
引用
收藏
页码:17 / 20
页数:4
相关论文
共 22 条
[1]   Genome variation of human papillomavirus types: Phylogenetic and medical implications [J].
Bernard, HU ;
Calleja-Macias, IE ;
Dunn, ST .
INTERNATIONAL JOURNAL OF CANCER, 2006, 118 (05) :1071-1076
[2]   Impact of HPV infection on the development of head and neck cancer [J].
Betiol, J. ;
Villa, L. L. ;
Sichero, L. .
BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH, 2013, 46 (03) :217-226
[3]  
Castellsague X., 2015, VACCINE
[4]   Critical Role of the Rb Family in Myoblast Survival and Fusion [J].
Ciavarra, Giovanni ;
Ho, Andrew T. ;
Cobrinik, David ;
Zacksenhaus, Eldad .
PLOS ONE, 2011, 6 (03)
[5]   Safety and immunogenicity of the HPV-16/18 AS04-adjuvanted vaccine in HIV-positive women in South Africa: A partially-blind randomised placebo-controlled study [J].
Denny, Lynette ;
Hendricks, Bronwyn ;
Gordon, Chivaugn ;
Thomas, Florence ;
Hezareh, Marjan ;
Dobbelaere, Kurt ;
Durand, Christelle ;
Herve, Caroline ;
Descamps, Dominique .
VACCINE, 2013, 31 (48) :5745-5753
[6]   Results of the first WHO international collaborative study on the standardization of the detection of antibodies to human papillomaviruses [J].
Ferguson, M ;
Heath, A ;
Johnes, S ;
Pagliusi, S ;
Dillner, J .
INTERNATIONAL JOURNAL OF CANCER, 2006, 118 (06) :1508-1514
[7]   Clinical and laboratorial study of HPV infection in men infected with HIV [J].
Figliuolo, Giuseppe ;
Maia, Jusimara ;
Jalkh, Alex P. ;
Miranda, Angelica E. ;
Ferreira, Luiz C. L. .
INTERNATIONAL BRAZ J UROL, 2012, 38 (03) :411-418
[8]   Human papillomavirus infection in oral fluids of HIV-1-positive men: prevalence and risk factors [J].
Gaester, Karen ;
Fonseca, Luiz A. M. ;
Luiz, Olinda ;
Assone, Tatiane ;
Fontes, Adriele Souza ;
Costa, Fernando ;
Duarte, Alberto J. S. ;
Casseb, Jorge .
SCIENTIFIC REPORTS, 2014, 4
[9]   Efficacy of Quadrivalent HPV Vaccine against HPV Infection and Disease in Males [J].
Giuliano, Anna R. ;
Palefsky, Joel M. ;
Goldstone, Stephen ;
Moreira, Edson D., Jr. ;
Penny, Mary E. ;
Aranda, Carlos ;
Vardas, Eftyhia ;
Moi, Harald ;
Jessen, Heiko ;
Hillman, Richard ;
Chang, Yen-Hwa ;
Ferris, Daron ;
Rouleau, Danielle ;
Bryan, Janine ;
Marshall, J. Brooke ;
Vuocolo, Scott ;
Barr, Eliav ;
Radley, David ;
Haupt, Richard M. ;
Guris, Dalya .
NEW ENGLAND JOURNAL OF MEDICINE, 2011, 364 (05) :401-411
[10]   PAPILLOMAVIRUS INFECTIONS AND HUMAN GENITAL CANCER [J].
HAUSEN, HZ ;
DEVILLIERS, EM ;
GISSMANN, L .
GYNECOLOGIC ONCOLOGY, 1981, 12 (02) :S124-S128