NERVE GROWTH-FACTOR AND P75(NGFR) FACTOR-RECEPTOR MESSENGER-RNA CHANGE IN RODENT CNS FOLLOWING STRESS ACTIVATION OF THE HYPOTHALAMO-PITUITARY-ADRENOCORTICAL AXIS

被引：36

作者：

FOREMAN, PJ

TAGLIALATELA, G

ANGELUCCI, L

TURNER, CP

PEREZPOLO, JR

机构：

[1] UNIV TEXAS, MED BRANCH, DEPT HUMAN BIOL CHEM & GENET, GALVESTON, TX 77550 USA

[2] INST RES SENESCENCE SIGMA TAU, POMEZIA, ITALY

[3] UNIV ROMA LA SAPIENZA, I-00185 ROME, ITALY

来源：

JOURNAL OF NEUROSCIENCE RESEARCH | 1993年 / 36卷 / 01期

关键词：

NEUROTROPHIN RECEPTOR; STRESS HIPPOCAMPUS; HYPOTHALAMUS; CORTICOSTEROID;

D O I：

10.1002/jnr.490360103

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The synthesis of nerve growth factor (NGF) by the hippocampus raises the possibility that NGF may play a role in the regulation of the hypothalamic-pituitary-adrenal axis (HPAA). Subchronic cold stress has been shown to activate the HPAA in a mild noninvasive manner, to stimulate serum glucocorticoid levels, and to perturb NGF binding in hippocampus and basal forebrain. One or repeated episodes of cold stress increased NGF mRNA levels in the hippocampus and p75NGFR mRNA levels in the basal forebrain. These changes were not due to elevated serum glucocorticoid levels since treatment with exogenous corticosterone had no effect on NGF and p75NGFR mRNA levels. Adrenalectomy did not prevent the stress induced increases in NGF and p75NGFR mRNA. (C) 1993 Wiley-Liss, Inc.

引用

页码：10 / 18

页数：9