COMPARATIVE-STUDY OF 3 AMNIOTIC-FLUID MARKERS IN PREMATURE RUPTURE OF MEMBRANES - FETAL FIBRONECTIN, ALPHA-FETOPROTEIN, DIAMINO-OXIDASE

被引：25
作者：
GAUCHERAND, P [1 ]
GUIBAUD, S [1 ]
AWADA, A [1 ]
RUDIGOZ, RC [1 ]
机构：
[1] HOP CROIX ROUSSE,CENT LAB,F-69004 LYON,FRANCE
来源：
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA | 1995年 / 74卷 / 02期
关键词：
ALPHA-FETOPROTEIN; BIOCHEMICAL DIAGNOSIS; DIAMINO-OXIDASE; FETAL FIBRONECTIN; PREMATURE RUPTURE OF MEMBRANES;
D O I：
10.3109/00016349509008918
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
Background. To study the comparative diagnostic value in premature rupture of membranes (PRM) of three amniotic components: fetal fibronectin (fFN), alphafetoprotein (AFP), diamino-oxydase (DAO). Methods. 131 pregnant women took part in our prospective study. Three samples were obtained successively for each patient in a random order. Two clinical situations were studied: group A of 68 women with clinical certain PRM and group B of 63 women with a highly unlikely PRM. Results. fFN is the best marker for diagnosis of PRM (sensitivity of 94% and specificity of 97%). AFP and DAO are complementary: the NPV is greater for AFP (87% against 84%) whereas the PPV is greater for DAO (95% against 86%). Conclusion. Apart from its value in predicting premature labor, vaginal fFN represents a diagnostic test of PRM with good specificity and sensitivity.
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收藏
页码：118 / 121
页数：4
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