INDUCTION OF PROGRAMMED CELL-DEATH (APOPTOSIS) IN MATURE LYMPHOCYTES

被引：27

作者：

LUCAS, M

SOLANO, F

SANZ, A

机构：

[1] Dpto de Bioquimica, Hospital Universitario V. Macarena, Facultad de Medicina, 41009 Sevilla

来源：

FEBS LETTERS | 1991年 / 279卷 / 01期

关键词：

POLYMYXIN-B; TUMOR PROMOTER; APOPTOSIS; NUCLEOSOME;

D O I：

10.1016/0014-5793(91)80239-Y

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The apoptosis of human peripheral blood lymphocytes was analyzed by the breakdown of DNA into oligonucleosome-sized fragments. The mature lymphocytes were rendered sensitive to apoptosis by either the omission of fetal bovine serum in the culture medium or the addition of polymyxin B. In the first case it was counteracted by phorbol myristate acetate. The possible involvement of protein kinase C in cell survival is pointed out.

引用

页码：19 / 20

页数：2

共 15 条

[1]

ARENDS MJ, 1990, AM J PATHOL, V136, P593

[2]

BOYUM A, 1968, SCAND J CLIN LAB INV, VS 21, P77

[3] CASCADE INDUCTION OF C-FOS, C-MYC, AND HEAT-SHOCK 70K TRANSCRIPTS DURING REGRESSION OF THE RAT VENTRAL PROSTATE-GLAND [J].