ACQUIRED FACTOR-VIII INHIBITOR ASSOCIATED WITH CHRONIC INTERFERON-ALPHA THERAPY

被引：0
|
作者：
STRICKER, RB
BARLOGIE, B
KIPROV, DD
机构：
[1] CALIF PACIFIC MED CTR,DEPT MED,DIV IMMUNOTHERAPY,SAN FRANCISCO,CA
[2] UNIV ARKANSAS MED SCI HOSP,DIV HEMATOL ONCOL,LITTLE ROCK,AR
来源：
JOURNAL OF RHEUMATOLOGY | 1994年 / 21卷 / 02期
关键词：
FACTOR VIII INHIBITOR; INTERFERON; DRUG REACTION; MULTIPLE MYELOMA; BONE MARROW TRANSPLANTATION;
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Therapeutic use of interferon-alpha (IFN-alpha) has been associated with the development of a variety of autoimmune disorders. We describe a patient who received chronic treatment with IFN-alpha following autologous bone marrow transplantation for multiple myeloma. The patient developed an antibody inhibitor directed against factor VIII coagulant protein (FVIIIC) leading to a fatal hemorrhagic diathesis. The association between IFN-alpha therapy and autoimmune complications deserves wider recognition and further study.
引用
收藏
页码：350 / 352
页数：3
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