DETECTION OF HEPATITIS-C VIRUS-RNA IN ACUTE NON-A, NON-B-HEPATITIS AS AN EARLY DIAGNOSTIC-TOOL

被引：17
作者：
KATO, N [1 ]
YOKOSUKA, O [1 ]
HOSODA, K [1 ]
ITO, Y [1 ]
OHTO, M [1 ]
OMATA, M [1 ]
机构：
[1] CHIBA UNIV,SCH MED,DEPT MED 1,CHUO KU,CHIBA 260,JAPAN
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1993年 / 192卷 / 02期
关键词：
D O I：
10.1006/bbrc.1993.1485
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The presence of hepatitis C virus RNA was examined in the sera of 32 patients with acute non-A, non-B hepatitis. Hepatitis C virus RNA was extracted from serum, reverse transcribed to cDNA and amplified by two rounds of polymerase chain reaction. Hepatitis C virus RNA was detected in all patients who developed anti-C100-3 as well as 79% who did not. These data suggest that hepatitis C virus accounts for most cases of acute non-A, non-B hepatitis whether anti-C100-3-positive or not. In addition, hepatitis C virus RNA was detected in the earliest serum samples, 9 ± 11 weeks before anti-C100-3, and thus may be valuable as a diagnostic marker for acute hepatitis C. © 1993 Academic Press. All rights reserved.
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收藏
页码：800 / 807
页数：8
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