ELIMINATION OF A BRAIN TRACT INCREASES ERRORS IN PATHFINDING BY FOLLOWER GROWTH CONES IN THE ZEBRAFISH EMBRYO

被引:55
作者
CHITNIS, AB
KUWADA, JY
机构
[1] UNIV MICHIGAN,DEPT BIOL,ANN ARBOR,MI 48109
[2] UNIV MICHIGAN,INST GERONTOL,ANN ARBOR,MI 48109
关键词
D O I
10.1016/0896-6273(91)90266-3
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The early zebrafish brain contains a simple axon scaffold of longitudinal tracts connected by commissures. Neurons in the nucleus of the posterior commissure (nuc PC) project growth cones along a specific route in this axonal scaffold, raising the possibility that specific axons in the early scaffold guide nuc PC growth cones. We tested this possibility by analyzing the behavior of nuc PC growth cones in embryos in which a portion of the scaffold, normally traversed by nuc PC growth cones, was surgically prevented from forming. Under these conditions nuc PC growth cones extended along both normal and aberrant pathways. This suggests that specific axons do provide guidance cues, since their removal leads to errors. However, these cues are not obligatory, since some growth cones still followed normal pathways.
引用
收藏
页码:277 / 285
页数:9
相关论文
共 23 条
[2]   EXPRESSION OF FASCICLIN-I AND FASCICLIN-II GLYCOPROTEINS ON SUBSETS OF AXON PATHWAYS DURING NEURONAL DEVELOPMENT IN THE GRASSHOPPER [J].
BASTIANI, MJ ;
HARRELSON, AL ;
SNOW, PM ;
GOODMAN, CS .
CELL, 1987, 48 (05) :745-755
[3]  
BERNHARDT RR, 1990, J COMP NEUROL, V302, P607
[4]  
CHITNIS AB, 1990, J NEUROSCI, V10, P1892
[5]   AXON GUIDANCE AND THE PATTERNING OF NEURONAL PROJECTIONS IN VERTEBRATES [J].
DODD, J ;
JESSELL, TM .
SCIENCE, 1988, 242 (4879) :692-699
[6]   GENETIC-ANALYSIS OF A DROSOPHILA NEURAL CELL-ADHESION MOLECULE - INTERACTION OF FASCICLIN-I AND ABELSON TYROSINE KINASE MUTATIONS [J].
ELKINS, T ;
ZINN, K ;
MCALLISTER, L ;
HOFFMANN, FM ;
GOODMAN, CS .
CELL, 1990, 60 (04) :565-575
[7]   CELL RECOGNITION DURING NEURONAL DEVELOPMENT [J].
GOODMAN, CS ;
BASTIANI, MJ ;
DOE, CQ ;
DULAC, S ;
HELFAND, SL ;
KUWADA, JY ;
THOMAS, JB .
SCIENCE, 1984, 225 (4668) :1271-1279
[8]   GROWTH CONE GUIDANCE IN INSECTS - FASCICLIN-II IS A MEMBER OF THE IMMUNOGLOBULIN SUPERFAMILY [J].
HARRELSON, AL ;
GOODMAN, CS .
SCIENCE, 1988, 242 (4879) :700-708
[9]   LOCAL POSITIONAL CUES IN THE NEUROEPITHELIUM GUIDE RETINAL AXONS IN EMBRYONIC XENOPUS BRAIN [J].
HARRIS, WA .
NATURE, 1989, 339 (6221) :218-221
[10]   THE CYCLOPS MUTATION BLOCKS SPECIFICATION OF THE FLOOR PLATE OF THE ZEBRAFISH CENTRAL-NERVOUS-SYSTEM [J].
HATTA, K ;
KIMMEL, CB ;
HO, RK ;
WALKER, C .
NATURE, 1991, 350 (6316) :339-341