VISCOELASTIC PROPERTIES OF PHARMACEUTICAL SEMISOLIDS .I. OINTMENT BASES

被引：48

作者：

DAVIS, SS

机构：

[1] Department of Pharmaceutics, School of Pharmacy, University of London, London

[2] Department of Analytical Pharmaceutical Chemistry and Pharmaceutics, School of Pharmacy, The University of Kansas, Lawrence, Kansas

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1969年 / 58卷 / 04期

关键词：

Creep compliance—ointment; Ointment bases—creep testing; Shear; continuous; creep—ointment viscoelasticity; Temperature effect—viscoelastic properties; Viscoelastic properties—ointment bases;

D O I：

10.1002/jps.2600580404

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The rheological evaluation of semisolids by continuous shear methods is limited in its application. However if materials are viscoelastic, their properties can be assessed in creep testing where fundamental parameters are provided and rheological behavior can be represented by mechanical models. Measurements have been made on a number of ointment bases over a range of temperature. The addition of small quantities of complex materials to paraffin ointment bases changes their behavior from elastic to viscoelastic. As many of the materials show a characteristic change in viscoelastic spectrum with temperature it is hoped that creep testing will provide a suitable method for the correct rheological evaluation of many important materials. Copyright © 1969 Wiley‐Liss, Inc., A Wiley Company

引用

页码：412 / &

共 37 条

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