ROLE OF SPLENECTOMY IN CHRONIC LYMPHOCYTIC-LEUKEMIA WITH MASSIVE SPLENOMEGALY AND CYTOPENIA

被引：9
作者：
MAJUMDAR, G
SINGH, AK
机构：
[1] Division of Haematology, UMDS, London, England, St. Thomas' Campus
来源：
LEUKEMIA & LYMPHOMA | 1992年 / 7卷 / 1-2期
关键词：
SPLENECTOMY; CLL; MASSIVE SPLENOMEGALY;
D O I：
10.3109/10428199209053612
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Fourteen cases of chronic lymphocytic leukaemia (CLL) and massive splenomegaly associated with anaemia and/or thrombocytopenia (stage C) with or without mechanical distress underwent splenectomy. Eleven regressed to stage A and 2 to stage B. All 6 patients with mechanical distress were relieved of their symptoms. Among 13 patients with anaemia, haemoglobin (Hb) level was normalised in 3, improved in 8 and showed no change in 2 cases. Among 13 patients with thrombocytopenia, platelet count was normalised in 10, improved in 1 and was unchanged in 2 cases. Mean Hb level increased from 89 g/1 to 125 g/1 and mean platelet count from 77 × 109/1 to 241 × 109/1 (p < 0.001 for both). Duration of response lasted for a mean period of 42.1 (CI 20.8-63.5) months. Mean survival after splenectomy was 44.5 months (CI 21.2-67.7). There was no operative mortality but 4 patients had significant post-operative morbidity. It is concluded that splenectomy is beneficial in advanced cases of CLL with massive splenomegaly and cytopenia. © 1992 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.
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页码：131 / 134
页数：4
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