CYTOKINE RECEPTORS

被引：20

作者：

GILLIS, S

机构：

[1] Immunex Research and Development Corporation, Seattle, WA

来源：

CURRENT OPINION IN IMMUNOLOGY | 1991年 / 3卷 / 03期

关键词：

D O I：

10.1016/0952-7915(91)90030-5

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The molecular characterization of cytokine receptors has progressed rapidly over the past 5 years as a result of availability of radiolabeled cytokines, as well as the identification or creation of cell lines that express significant numbers of receptors at the cell surface. This explosion in research effort has led to establishment of multiple cytokine-receptor gene families and the realization that inhibition of cytokine function at the level of ligand-receptor interaction may be an important area for therapeutic drug development.

引用

收藏

页码：315 / 319

页数：5

相关论文

共 14 条

[1] A NUCLEAR FACTOR FOR IL-6 EXPRESSION (NF-IL6) IS A MEMBER OF A C/EBP FAMILY [J].

AKIRA, S ;

ISSHIKI, H ;

SUGITA, T ;

TANABE, O ;

KINOSHITA, S ;

NISHIO, Y ;

NAKAJIMA, T ;

HIRANO, T ;

KISHIMOTO, T .

EMBO JOURNAL, 1990, 9 (06) :1897-1906

[2] DETECTION AND CHARACTERIZATION OF HIGH-AFFINITY PLASMA-MEMBRANE RECEPTORS FOR HUMAN INTERLEUKIN-1 [J].

DOWER, SK ;

KRONHEIM, SR ;

MARCH, CJ ;

CONLON, PJ ;

HOPP, TP ;

GILLIS, S ;

URDAL, DL .

JOURNAL OF EXPERIMENTAL MEDICINE, 1985, 162 (02) :501-515

[3] REGULATION OF ALLOREACTIVITY INVIVO BY A SOLUBLE FORM OF THE INTERLEUKIN-1 RECEPTOR [J].

FANSLOW, WC ;

SIMS, JE ;

SASSENFELD, H ;

MORRISSEY, PJ ;

GILLIS, S ;

DOWER, SK ;

WIDMER, MB .

SCIENCE, 1990, 248 (4956) :739-742

[4]

FOXWELL BMJ, 1990, IMMUNOLOGY, V69, P104

[5]

HOHMANN HP, 1989, J BIOL CHEM, V264, P14927

[6] PURIFICATION OF HEMOPOIETIN-1 - A MULTILINEAGE HEMATOPOIETIC GROWTH-FACTOR [J].

JUBINSKY, PT ;

STANLEY, ER .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1985, 82 (09) :2764-2768

[7]

LEE HK, 1990, J IMMUNOL, V144, P3431

[8]

MALISZEWSKI CR, 1990, J IMMUNOL, V144, P3028

[9] THE MURINE INTERLEUKIN-4 RECEPTOR - MOLECULAR-CLONING AND CHARACTERIZATION OF SECRETED AND MEMBRANE-BOUND FORMS [J].

MOSLEY, B ;

BECKMANN, MP ;

MARCH, CJ ;

IDZERDA, RL ;

GIMPEL, SD ;

VANDENBOS, T ;

FRIEND, D ;

ALPERT, A ;

ANDERSON, D ;

JACKSON, J ;

WIGNALL, JM ;

SMITH, C ;

GALLIS, B ;

SIMS, JE ;

URDAL, D ;

WIDMER, MB ;

COSMAN, D ;

PARK, LS .

CELL, 1989, 59 (02) :335-348

[10] SOLUBLE CYTOKINE RECEPTORS ARE PRESENT IN NORMAL HUMAN-URINE [J].

NOVICK, D ;

ENGELMANN, H ;

WALLACH, D ;

RUBINSTEIN, M .

JOURNAL OF EXPERIMENTAL MEDICINE, 1989, 170 (04) :1409-1414