SYNTHESIS OF 1-(2,3-DIDEOXY-2-FLUORO-BETA-D-THREO-PENTOFURANOSYL)CYTOSINE (F-DDC) - A PROMISING AGENT FOR THE TREATMENT OF ACQUIRED-IMMUNE-DEFICIENCY-SYNDROME

被引：79
作者：
OKABE, M
SUN, RC
ZENCHOFF, GB
机构：
[1] Roche Research Center, Hoffmann-La Roche Inc., Nutley
来源：
JOURNAL OF ORGANIC CHEMISTRY | 1991年 / 56卷 / 14期
关键词：
D O I：
10.1021/jo00014a013
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A new and practical synthesis of a fluorinated analogue of 2',3'-dideoxycytidine (ddC), 1-(2,3-dideoxy-2-fluoro-beta-D-threo-pentofuranosyl)cytosine (F-ddC), is described. The key feature in the synthesis is the use of the selectively protected 2,4,5-trihydroxypentanoic acid derivative 15 as a chiral pool synthon.
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页码：4392 / 4397
页数：6
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