INHIBITION OF LUNG METASTASIS IN MICE INDUCED BY B16F10 MELANOMA-CELLS BY POLYPHENOLIC COMPOUNDS

被引:182
|
作者
MENON, LG [1 ]
KUTTAN, R [1 ]
KUTTAN, G [1 ]
机构
[1] AMALA CANC RES CTR, KERALA 680353, INDIA
关键词
ANTIMETASTATIC ACTIVITY; POLYPHENOLS;
D O I
10.1016/0304-3835(95)03887-3
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Several polyphenolic compounds were tested for the inhibition of lung metastasis induced by B16F10 melanoma cells in mice. Oral administration of polyphenols such as curcumin and catechin at concentrations of 200 nmol/kg body weight were found to inhibit the lung metastasis maximally as seen by the reduction in the number of lung tumor nodules (80%). Other polyphenols which inhibited the lung tumor nodule formation were rutin (71.2%), epicatechin (61%), naringin (27.2%) and naringenin (26.1%). The polyphenols which did not inhibit lung tumor nodule formation were quercetin, morin and ellagic acid. Consequent to the inhibition of the lung tumor nodules, the life span of animals treated with polyphenols was also found to be increased. Curcumin (143.85%), catechin (80.81%) and rutin (63.59%) had maximal increase in life span. The results indicate a possible use of these compounds in arresting the metastatic growth of tumor cells.
引用
收藏
页码:221 / 225
页数:5
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